You said your son has some disabilities? Could he have ADHD? This can also be your wife's problem, many adults have ADHD as well that are undiagnosed. I have ADHD children...they are not told to clean their room and left for themselves, because of their disability they need help to organize and put away. I help them do a deep clean once a month or every other month depending on the mess. Inbetween the deep clean (where I help them decide to throw away) they are told in steps what to do. For example I tell them a step "pick up toys and put in toy bucket", after this task is completely finished I say "pick up clothes and put in clothes basket", and so on until everything is in its place. My kids are taught everything has a place. If it doesn't belong to any place it gets thrown away. If they want to keep it they have to find what place it belongs. I let my children do the work and I supervise. I only do physical work on deep clean day.
However, I suspect this really isn't about the housework but more about the spouse's attitude toward what you feel is important.